Muscle loss and weight loss medications like Ozempic and Mounjaro are raising new questions. These medications can support rapid fat loss, but if not managed properly, they may also lead to a loss of muscle.

And muscle isn’t just about strength, it’s essential for stability, energy, and healthy ageing. Let’s break down what we know, what we don’t, and how to stay strong through it all.

Why Muscle Matters More Than Ever

Muscle is more than aesthetics. It supports posture, protects joints, balances blood sugar, and keeps your metabolism steady.

When you lose muscle, your risk of injury increases. You may feel weaker, more tired, and less stable, even if the number on the scale is dropping. For long-term health, preserving muscle is just as important as reducing fat.

Why Rapid Weight Loss Can Affect Muscle

Ozempic and Mounjaro belong to a class of medications called GLP-1 receptor agonists. They reduce appetite and help people lose weight quickly. But fast weight loss often means losing more than just fat, especially without a strength training routine in place.

The body can break down muscle as well, leading to changes in strength, shape, and energy. “Ozempic face”, a hollowed look due to facial fat loss, is one visible sign, but what’s happening deeper in the body is just as important.

What the Research Says (And Doesn’t Say Yet)

Current research focuses on the impressive fat loss effects of GLP-1 medications. There’s less data on their long-term impact on muscle mass.

We don’t yet know how much muscle is lost, how quickly, or what the recovery looks like once the medication stops. That’s why taking proactive steps to preserve muscle is so important while you’re on the medication, and after.

Are You Losing Fat or Muscle?

It’s not always easy to tell. Scales can’t show what type of weight you’re losing, but your body might give you clues:

• Are your limbs shrinking more than your waistline?

• Do you feel weaker or more fatigued during workouts?

• Are you struggling with balance, posture, or daily activities?

Body composition scans like DEXA, or even simple strength tests like grip strength, can offer more insight. At Lift Inner West, we focus on performance-based markers, not just what the scale says.

How to Protect Muscle During Weight Loss

You don’t have to accept muscle loss as part of the process. Here’s how to protect your strength:

• Lift weights 2–3 times a week. Focus on big, functional movements.

• Prioritise protein at every meal. Think eggs, tofu, yoghurt, lean meats, legumes.

• Stay active every day. Even light walking supports muscle and joint health.

• Don’t skip rest. Recovery is when muscles rebuild.

• Work with a coach or health pro. Personalised advice beats guesswork.

What We Do at Lift Inner West

At Lift Inner West, we support people using weight loss medications and those who aren’t. Our approach is always built around strength, structure, and sustainability.

We offer:

• Custom strength programs that support your energy and goals

• Education around nutrition and how to fuel your training

• Progress tracking that focuses on strength, not just weight

• Supportive coaching to help you build habits that last long after medication ends

If you’re worried about muscle loss, you don’t need to go it alone.

Muscle loss and weight loss medications don’t have to go hand in hand. With the right training, nutrition, and support, you can lose fat, stay strong, and build a body that works for your life, not just your goal weight.